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Figure 3 4.3 Fatty acid metabolic dysregulation induces hyperuricemia in gout pathogenesis Hyperuricemia is an established modifiable risk factor for gouty arthritis (GA), which directly influences disease progression through dynamic fluctuations in serum urate levels ( de novo fatty acid synthesis (DNL) induce purine salvage synthesis pathways to promote excessive uric acid synthesis ( HIF-1 serves as the primary molecular mediator of the hypoxic response

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