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doi:10.1016/j.cmet.2018.02.011 High-Dose Vitamin C IV: Collagen Synthesis and Photoprotection Intravenous vitamin C at 10-25g achieves plasma concentrations of 13,000-20,000 umol/L 70-100x higher than maximum oral absorption of 220 umol/L

Graf and Kastins review catalogues a strikingly broad reported activity profile effects on stress tolerance, pain, thermoregulation, endocrine secretion, and withdrawal states while concluding that the physiological functions and mechanism remain to be established. [2] Schneider-Helmert and Schoenenberger similarly reported that DSIP raised alertness and performance during the waking state and appeared to modulate stress tolerance and coping

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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice