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In cholesterol metabolism, H 2 O 2 /O/OH/LOOH inhibit cholesterol synthesis by oxidatively modifying HMG-CoA reductase [195, 196]

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In the first step, the oxidized (Fe 3+ ) form of the enzyme binds the reduced drug substrate

139 : 271279 Carbonari M, Cibati M, Cherchi M, Sbarigia D, Pesce AM, DellAnn L, Modica A and M (1994) Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus-infection and cancer chemotherapy by a novel flow immunocytometric method