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4 Dosing regimens are aimed at a target steady-state concentration of 10 mg/L, which has been associated with adequate reduction of temperature and pain scores in children

doi: 10.1111/apt.18138 98 VillumsenMScheldeABJimenez-SolemEJessTAllinKH

The transdermal composition of claim 2 wherein polymer is selected from one or more of polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly (Butyl methacrylate, methyl methacrylate), cellulose polymers (carboxymethylcellulose, ethyl cellulose, hydroxypropylmethylcellulose hydroxypropylcellulose), polyvinylpyrrolidone, polymer of acrylic acid crosslinked with allyl ethers of polyalcohols (carbomer / carbopol)