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The decision belongs to the prescriber, weighing your full clinical picture

Since chronic hyperglycemia itself impairs -cell function [12], pharmacologic interventions to reduce hyperglycemia may improve -cell function and restore -cell glucose sensitivity [13]

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Dual-agonist and tri-agonist therapies have demonstrated superior outcomes in weight loss, lowered blood sugar and lipid levels, restoration of tissue function, and enhancement of overall substrate metabolism compared to using GLP-1R agonists alone