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Like semaglutide, tirzepatide is a GLP-1 receptor agonist, but it also targets another hormone called GIP (glucose-dependent insulinotropic polypeptide)

Clinical trial summaries and contemporary analyses show a broad incidence range for nauseacommonly cited as 2050% depending on dose and agentwith most episodes being mild to moderate

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Clinical trial participants who took tirzepatide, the drug sold as Zepbound, lost an average of 50 pounds (22.8 kilograms) over 72 weeks, while those who took semaglutide, or Wegovy, lost about 33 pounds (15 kilograms)