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We then warped the a priori defined prefrontal and limbic ROIs, initially established in MNI space, back into subject-specific ASL space using the inverse transformation matrices obtained from this two-step registration process

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Glutathione reductase (GR), an NADPH-dependent enzyme, continuously regenerates reduced glutathione (GSH) from its oxidized form (GSSG), thereby maintaining the intracellular reducing environment required for effective antioxidant defense, proper enzymatic activity, and redox-dependent signaling pathways [36]