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Tissue Maintenance, Aging, and Longevity-Oriented Research Because IGF-1 signaling is central to cell maintenance and repair, IGF-1 LR3 is also of interest in aging-related studies: Lifespan Correlations: Research in animal models (including mice, cows, and pigs) has explored correlations between IGF-1 levels, tissue integrity, and functional decline, using IGF-1 LR3 or similar constructs as tools to manipulate signaling

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Initial studies also report that IGF-1 LR3 may lead to the growth of mucosa inside the intestines

(1997) reported that IGF-1 LR3 increased tumor growth in tumor-bearing catabolic rats