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While our in vitro study demonstrates that linagliptin-induced inhibition of DPP-IV activity prevents conversion of synthetic full-length NPY/PYY to NPY 336/ PYY 336 , further studies are required to confirm if DPP-IV inhibitors can also modulate endogenous circulating levels of NPY 336/ PYY 336

Both dietary approaches, when integrated with semaglutide therapy, have the potential to preserve lean body mass, reduce gastrointestinal adverse events, and enhance adherence through improved satiety and tolerability