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In the area of antihepatic fibrosis, ISL could inhibit Annexin A2 expression and block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway (Liu et al., 2023), yet, QE decreased hepatic mRNA levels of SphK1 and NLRP3 (Salama et al., 2024)

It was revealed that fumarate, possessing a weak electrophilic property, modifies KEAP1 cysteine residues, resulting in the stabilization of NRF2