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282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response

In recent years, new medications have emerged to help manage weight loss in conjunction with lifestyle modifications

In todays clinical environment, successful obesity care often involves adapting treatment over time rather than expecting a single medication to meet every patients needs indefinitely, said co-author Jaime Almandoz, M.D., M.B.A., Professor of Internal Medicine in the Division of Endocrinology and Medical Director of UTSWs Weight Wellness Program