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reported that allopurinol and nicotinamide inhibit the proliferation of OFs induced by superoxide ( in vitro study performed in cultured OFs from patients with GO, incubated with interferon (IFN-) and tumor necrosis factor (TNF-) in the presence of nicotinamide (47)

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, gastrointestinal tract, muscle, nerve, brain lesions healing)) (5-7, 9), and cytokine and growth factor generation and early extracellular matrix (collagen) formation (44)