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Commenters stated that these additional provisions are necessary to protect individuals and other healthcare entities from discrimination on the basis of their moral and religious beliefs

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It may additionally influence bone metabolism through immune system modulationvia the secretion of microbial metabolites that interact with immune cells (e.g., T cells, B cells), activate the intestinal mucosal immune response, and induce the production of pro- or anti-inflammatory mediators and cytokines involved in the regulation of bone remodeling (210)