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Keywords: autonomic nervous system, diabetic complications, brain nuclei, cardiovascular diseases, diabetes, obesity Introduction Type 2 diabetes (T2D) is currently a severe global public health issue, owing to the huge burden associated with management of microvascular and macrovascular complications

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Examples include: Wellbutrin, an antidepressant that can be used off-label for weight loss and smoking cessation Metformin, which is FDA approved to treat Type 2 diabetes and is also often used off-label for polycystic ovarian syndrome (PCOS) Contrave, a combination of Wellbutrin and naltrexone, a drug developed for the treatment of substance disorders Qsymia, a combination of the prescription weight loss drug phentermine and the anti-epilepsy drug Topamax (topiramate), which aids in weight loss when combined with a proper diet and exercise It may also decrease binge eating

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