A role for NAC in supporting mitochondrial metabolism has been shown in preclinical models of autism spectrum disorder, reviewed in Frye and Berk, 2019 [9], and promising, if mixed, results have been seen in some aspects of autism spectrum disorder in the limited number of studies conducted to date [5, 9]
10.1093/nar/28.1.27 Nucleic Acids Res
This indicates that plant extract therapy cannot be used as monotherapy, although it has a great potential to assist treatment (Lin and Huang 2009)
By integrating evidence on inflammatory signalling, immune-metabolic dysfunction, microbiota-driven immune priming, barrier integrity and intercellular transfer mechanisms, we aim to delineate in this review how peripheral immunity shapes -syn propagation and central neurodegeneration and to highlight translational opportunities arising from this immune-centric view of PD