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Good Clinical Practices (ICH GCPs) In 1997, country specific Good Clinical Practices guidelines were harmonized into a global entity: International Committee on Harmonization of Good Clinical Practices (ICH-GCP)

FIGURE 1 Maternal 2-Hydroxy-4-Methylselenobutanoic Acid Supplementation During Gestation Reduced Endoplasmic Reticulum Stress in the Jejunum of Newborn and Weaning Piglets To assess whether maternal HMSeBA supplementation could regulate intestinal ER stress level of their offspring, we analyzed the ER stress related indexes in the jejunum of newborn piglets and LPS challenged weaned piglets

Early supplementation can help maintain optimal levels and prevent the deficiency from progressing

Following the fast, mice received an IP injection of saline, DA-GIP (1 mg/kg), Ex-4 (0.02 mg/kg), or DA-GIP and Ex-4 given simultaneously