novo nordisk semaglutide announced headline results from STEP UP, a phase IIIb trial investigating subcutaneous 7.2 mg for obesity Ozempic maker Novo Nordisk says

They can assess your individual needs, discuss the risks and benefits, and help you determine if these medications are right for you

If you decide to undertake self-injection, always consult a nurse practitioner or doctor to learn the proper method of identifying and cleaning the injection site, administration and how-to properly open and clean a vial

Freezing causes the water to expand, potentially damaging the peptide structure

Add 1,000 L (1 mL) of reconstitution solvent to the 1 mg vial This yields a 1 mg/mL (1,000 g/mL) stock solution To achieve 100 g/mL working stock: Dilute 100 L of 1 mg/mL stock into 900 L of PBS or cell culture medium yields 100 g/mL in 1 mL To achieve 10 ng/mL in a 5 mL experiment: Take 0.5 L of 100 g/mL working stock + 4,999.5 L of medium Alternatively: dilute to an intermediate concentration to reduce pipetting error Use a dilution series approach (stock working stock final experimental concentration) to minimize pipetting inaccuracy at nanogram-level concentrations