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Additionally, melatonin can promote, in mitochondria, the formation of the apoptosis-inducing factor (AIF) precursor protein that promotes cell death by triggering chromatin condensation and DNA fragmentation [47]

If lifestyle changes are insufficient, a multimodal treatment strategy will be needed to achieve the requisite blood pressure, lipid profile, and blood glucose control targets

The role of the aberrant vascular endothelium in the development of cardiovascular pathologies, including atherosclerosis, ageing, hypertension, obesity, and diabetes, has been widely recognized (93)

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