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Ethics approval All procedures followed were in accordance with the international standards of animal protection and the ethical principles of the National Council of Animal Experimentation and was approved by the Ethics Committee on Animal Use of the University Federal of Ouro Preto (#2014/17)

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Contact your healthcare provider within 24 hours for: New or worsening abdominal pain that is moderate in severity and localized to the right upper abdomen Recurrent episodes of pain after eating, particularly fatty meals Persistent nausea or vomiting that is worsening rather than improving over time Any abdominal symptoms that concern you or differ from your usual experience with the medication Routine follow-up appointments should include discussion of any gastrointestinal symptoms, weight loss patterns, and overall tolerance of the medication