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A 2025 meta-analysis found that weight decreased by about 0.04 kg per day, while fat-free mass decreased by about 0.007 kg per day

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In addition, the GLP-1 can inhibit postprandial gastric emptying and reduce gastric acid secretion, inhibit gastric and duodenal peristalsis by inhibiting vagus nerve, and increase the pressure of pylorus, thus reducing appetite, causing a reduction in body weight and participating in the so-called ileal braking effect (35)

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