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doi: 10.3389/fphar.2026.1755175 Received 26 November 2025 Revised 21 January 2026 Accepted 20 February 2026 Published 09 March 2026 Volume 17 - 2026 Edited by Roland Bcker, Charit University Medicine Berlin, Germany Reviewed by Mark Lloyd Dapar, Central Mindanao University, Philippines Kishor Jain, Sinhgad Institutes, India Updates Copyright 2026 Kayesh, Kohara and Tsukiyama-Kohara

Key Ingredients and Their Benefits Glutathione Glutathione is a potent antioxidant known for its skin-brightening properties

Similarly, 2,2-bipyridine, a fast-acting iron chelator that acts similarly to DFO, protects LAMP-2 knockdown cells from tributyl phosphate (THP)-induced cell death in human RPE-19 cells and in primary fetal retinal pigment epithelium (52)

Why is oral glutathione described as a poor delivery route