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10.1016/S0031-9422(00)98212-8 Phytochemistry 28 LancasterJ

Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)

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Experimental studies in animal models and in vitro systems suggest that DSIP can influence the release of hormones such as growth hormone, luteinizing hormone, and adrenocorticotropic hormone through both hypothalamic and pituitary-level mechanisms [8]