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Interaction with GLP-1 was demonstrated via cross-linking, surface plasmon resonance (SPR) and isothermal titration calorimetry, giving affinity constants for GLP-1 of 46144 nM

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3g and Supplementary Table 1)

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81 At the cellular level, GLP1R stimulation restores mitochondrial membrane potential, enhances ATP generation, and promotes mitophagy, thereby improving neuronal bioenergetics and redox balance

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