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182,183 In neuroblastoma, overexpression of ARG1 can increase AKT and ERK phosphorylation and promote cell proliferation

Treating insulin resistance may reduce androgen activity over time, which is one reason metformin, movement, sleep and food-pattern changes can sometimes improve acne or unwanted hair growth

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Similarly, genes associated with mitochondrial activity, including components of the respiratory chain and TCA cycle, are downregulated, leading to decreased ATP production and impaired redox balance [41,42,43,44,45,46]