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Oral (systemic) medication can include antibiotics, retinoids or hormonal agents (i.e

Persistent, severe, or worsening headaches should always be evaluated by a medical provider, especially if accompanied by visual changes or nausea

Individuals with ARTHS present with developmental delay, cognitive impairment (100% penetrance), delay or absence of speech (100%), facial dysmorphism (85%), feeding difficulties (78%), and neonatal hypotonia (76%) in a study of 76 individuals with KAT6A mutations (Kennedy et al, 2019)