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Positron emission tomography (PET) imaging studies using the high-affinity sigma-1 (-1) receptor selective PET tracer [18F]1-(3-Fluoropropyl)-4-[4-cyanophenoxy) methyl]piperidine ([18F]FPS) as a radioligand suggest that neurosteroids including DHEA bind to -1 receptors in vivo (261)

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Microdosing offers a low-dose approach that may minimize side effects, improve tolerance, lead to greater adherence, and have low out-of-pocket costs