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The Journal of clinical and aesthetic dermatology, 12(4), 4045

Patent protection runs into the 2030s, so generic versions are not near

In mice, intermittent fisetin supplementation (50 mg/kg, 3 days every two weeks) cleared aging cells, restored glucose tolerance, and suppressed aging genes like p16 and p21

Because this phase typically peaks and begins transitioning into the remodeling phase around the 21-to-30-day mark, a 4-week administration window provides the necessary stimulus exactly when the cellular machinery is most active [3, 5]