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The risk of gastrointestinal adverse events is increased with GLP-1RA therapy but these effects tend to be mild-to-moderate and transient, and are not the reason for observed weight loss

Published online May 1, 2024:12-18

Experiences from peptide receptor radionuclide therapy (PRRT), where diagnostic and therapeutic pairs such as 68 Ga/ 177 Lu-DOTA-exendin are co-developed, may offer valuable insights for designing biomarker-guided clinical trials in GLP-1R-targeted nanomedicine

Progress will require crosssector dialogue among actuaries, clinicians, PBMs, manufacturers, and policymakers to align coverage, clinical practice, and evidence generationturning therapeutic promise into measurable, equitable value