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For example, in fish GPX4 activity contributes to a greater extent to total GPX activity, [19] GPX4a is the most highly expressed selenoprotein mRNA (in contrast to mammals where it is GPX1 mRNA) [20] and GPX4a appears to be highly inducible to changes within the cellular environment, such as changes in methylmercury and selenium status

Byrd AL, Deming C, Cassidy SKB, Harrison OJ, Ng WI, Conlan S, Belkaid Y, Segre JA, Kong HH

The emergence of intelligent, responsive nanocarriers may help NADs interact with complex environmental changes, responding to specific in vivo changes, such as pH, redox conditions, or external stimuli (ultrasound, light, magnetic fields, and electric fields)