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Semaglutide incorporation into the membrane with SNAC To directly observe the mechanism of peptide permeation in the presence of SNAC computationally, we performed unbiased C p HMD simulations with a system containing 400 SNAC molecules (periodic box size: 11 nm 11 nm 15 nm), semaglutide, and a model POPC/cholesterol epithelial membrane (see Fig