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However, the microbial diversity extends far beyond what is covered by reference databases and segregation of gut communities into specific bacterial species therefore remains a largely unsolved problem

IGF-1, as a nutrient-responsive growth factor, activates NF-B and the expression of downstream genes (Ccdn1, Vegf, Birc5 and Ptgs2) to promote the growth of pancreatic cancer in vitro and in vivo (88)