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For each peptide, we performed also ITC and fitted a 1:1 binding model to the thermogram (Fig

The body composition substudy showed that lean mass loss was not unusually high relative to the fat being lost, which pushes back on the worry that these drugs just melt muscle

Insulin resistance and metabolic status Individuals with significant insulin resistance, including those with type 2 diabetes or prediabetes, often experience slower initial weight loss

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