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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]

Although the rectal route bypasses the respiratory tract, systemic effects could theoretically still occur, and patients with asthma should be monitored closely

Oxaliplatin-Induced Cold Hypersensitivity Is Due to Remodelling of Ion Channel Expression in Nociceptors