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Pernicious anaemia , an autoimmune condition affecting approximately 0.1-0.2% of the UK population (higher in older adults), destroys gastric parietal cells that produce intrinsic factora protein essential for B12 absorption in the terminal ileum
High NNMT activity has also been linked to: Poor mitochondrial function Increased oxidative stress Accelerated fat storage Inhibiting this enzyme helps reverse those metabolic imbalances
Its regenerative effects also extend to hair growth and tissue repair, making it popular in cosmetic and therapeutic applications
However, high B12 levels in the blood can be a sign of underlying kidney or liver disease, indicating that these organs are struggling to get rid of excess B12
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