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J Clin Investig 91(1):301307 Nishizawa M, Nakabayashi H, Kawai K et al (2000) The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor

Future advances in structural biology, computational modeling, peptide engineering, and patient stratification are expected to accelerate systematic exploitation of genetically validated peptide targets, converting biological promise into clinical reality ( Statements Author contributions SN: Resources, Investigation, Software, Visualization, Conceptualization, Validation, Writing review and editing, Supervision, Formal Analysis, Project administration, Writing original draft, Methodology, Data curation

Leveraging PRO data beyond the label While PRO data are often used to support regulatory approval decision making and labeling, they will continue to have increasing importance beyond the label

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