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To make the hEC surface charge more positive the glycocalyx of hECs was digested with neuraminidase enzyme (1 U/ml, 1-h pretreatment) or cultures were treated with cationic lipid 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH

The altered skin sensation has not been reported in the PIONEER-PLUS study or with injectable semaglutide 2.4 mg and its aetiology will need to be explored further in future studies

Metabolism is the complex series of chemical reactions that convert food into energy

By converting systemic delivery into a targeted, antigen-specific tolerogenic intervention, this MSN/CeNP platform exemplifies how biomaterials can reshape peripheral immunity to halt neuroinflammation and demyelination in MS