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According to one study, patients with severe cases of COVID-19 often present with comorbidities that have already done significant damage to the endothelium

No reason to expect significant rebound or withdrawal

The authors recruited 30 adults (aged 60 to 80 years) with subjective cognitive decline, a condition associated with objective cognitive decline and Alzheimers disease

Genome-wide analyses reveal thousands of differentially methylated sites affecting steroid hormone signaling and inflammation pathways ( Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis