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The programme spans multiple trials targeting distinct endpoints: On 21 May 2026 Eli Lilly reported topline results from TRIUMPH-1, the pivotal Phase 3 obesity trial and the programme's first Phase 3 efficacy readout: in 2,339 adults, mean weight loss at the 80-week primary endpoint reached 19.0% (4mg), 25.9% (9mg), and 28.3% (12mg) versus 2.2% for placebo (Eli Lilly investor release

These benefits occur quickly following treatment initiation, suggesting that GLP-1 medicines may reduce cardiovascular events, at least in part, through weight loss-independent mechanisms

Injection solution (ampoules or vials with powder for solution preparation) Effects observed in animal studies usually after several days to several weeks of therapy No clear recommendations

Kaila, K., Price, T