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While both fungal acne and closed comedones can appear similar, several key differences help in distinguishing between the two: Feature Fungal Acne Closed Comedones Appearance Itchy, red bumps White or flesh-colored bumps Itchiness Yes No Common Locations Chest, back, forehead Face (especially forehead, chin, cheeks) Causes Overgrowth of Malassezia yeast Clogged hair follicles due to oil and dead skin Treatment Antifungal medications Exfoliation, retinoids, salicylic acid Fungal acne, medically known as Pityrosporum folliculitis, is often exacerbated by warm, humid environments, making it more prevalent in tropical climates or during the summer months

Funding This work was supported by the National Natural Science Foundation of China (32002184 to BW), the ZhiYuan project of Inner Mongolia Medical University (ZY0120025 to LS), and the Key Technology Research, Development and Transformation Projects of Inner Mongolia (2021GG0402 to YD and 2022YFSH0102 to YM)

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