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In a systematic review of 10 clinical trials in patients with HIV lipodystrophy, tesamorelin was effective in reducing VAT and increasing lean body mass and did not alter subcutaneous adipose tissue (146), and increased GH and IGF-I while insulin and glucose levels are unchanged indicating preservation of insulin sensitivity (147150) ( Table 1 )
If using a particularly thin gauge needle (31G or smaller), consider using a slightly larger gauge (29G or 28G) for reconstitution, then switching to the finer needle for drawing doses
That cost is increasingly unsustainable for payers in the U.S., and prohibitive for people whose insurance doesnt cover the drug
This dose is used to start people off as it has a lower risk of side effects
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