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What This Means for Patients The progression from single agonist (semaglutide) to dual agonist (tirzepatide) to triple agonist (retatrutide) demonstrates that targeting multiple complementary pathways can produce incrementally better outcomes

These persistence patterns reflect a combination of factors, including side effects, cost barriers, and the chronic nature of obesity treatment, and have important implications for projecting long-term cost offsets and population health outcomes

The pooled RR for sICH was 1.65 (95% CI: 1.212.23, p = 0.003), indicating a significantly higher risk of sICH in the EVT group

This hormone, GLP-1, is produced by the intestine and plays a role in blood glucose (sugar) control and appetite