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Metformin remains the first-line oral agent for most patients with type 2 diabetes, unless contraindicated, and should be continued alongside any alternative therapy unless there are specific reasons for discontinuation, as recommended by NICE

How the FDA Approval Process Works For readers unfamiliar with FDA drug approval, here is how the remaining steps typically unfold: Step 1: Phase 3 Trial Completion Retatrutide is currently in this stage , with the core weight-management readouts (TRIUMPH-1, -2, -3, -4 and TRANSCEND-T2D-1) now complete

Pharmacol Res 58:262270 Lushchak VI (2012) Glutathione homeostasis and functions: potential targets for medical interventions