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Ohtsuki M, Okubo Y, Komine M, Imafuku S, Day RM, Chen P, Petric R, Maroli A, Nemoto O (2017) Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: efficacy, safety and tolerability results from a phase 2b randomized controlled trial

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It is important to note that MC4R potency correlates well with observed clinical weight loss

For best results, reconstitute the lyophilized powder with sterile bacteriostatic water or saline solution and maintain strict sterile technique during experimental procedures