Key variants in genes like GLP1R (rs6923761), GIPR (rs1800437), and FTO (rs9939609) influence how sensitive your receptors are to these drugs and how your metabolism handles weight loss
Overlap between GLP1RA-related metabolites We found that metabolites shared between analyzed GLP1RA networks are associated with Galactose metabolism (ATP, ADP, alpha-D-Glucose, D-Fructose, D-Glucose, Glucose 6-phosphate, Pyrophosphate, Sucrose, Water), neomycin, kanamycin and gentamicin biosynthesis, starch and sucrose metabolism, arginine and proline metabolism but also nitric oxide-related pathways, platelet homeostasis (ATP, ADP, citrulline, cyclic GMP, guanosine triphosphate, hydrogen ion, L-arginine, NADPH, nitric oxide, oxygen, pyrophosphate) and VEGF-related pathways (ATP, ADP, citrulline, guanosine triphosphate, hydrogen ion, L-arginine, NADPH, nitric oxide, oxygen)
Nutrients, 14 (17), 3459
GLP-1 is cut from a precursor protein called proglucagon, encoded by the GCG gene