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Higurashi, T

Clinical outcome: Mucositis, stomatitis Severe myelosuppression (anaemia, leukopenia, thrombocytopenia) Nephrotoxicity, hepatotoxicity Life-threatening infections, bleeding High-risk groups: Elderly Patients with renal impairment Patients on high-dose methotrexate (oncology use) Concomitant nephrotoxic drugs Advice: Avoid NSAIDs with high-dose methotrexate

[DOI] [PubMed] [Google Scholar] 44.Mahdavi S, Khodarahmi P, Roodbari NH

La falta de esta molcula tambin puede deberse a componentes genticos que provocan problemas en su sntesis, malabsorcin intestinal o problemas hepticos