glp-1 signaling Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research GLP-1R and Diabetes

Pharmacokinetics (ADME) Absorption Well absorbed orally Rapid onset Distribution Highly protein bound (~99%) Metabolism Mainly hepatic metabolism Glucuronidation is significant Half-life About 23 hours But effect lasts longer due to enzyme inhibition Excretion Mainly via bile/feces Some renal excretion --- 5

Rebouche and Chenard, 1991)

Description Cagrilintide is a long-acting amylin analog peptide being researched for its role in appetite regulation, weight management, and metabolic control

A New Oral Option for Diabetes and Obesity HS-10270 is a novel oral formulation of a GLP-1 receptor agonist designed to help manage blood sugar levels and promote weight losstwo key therapeutic goals for patients with type 2 diabetes and obesity