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These include leptin sensitizers, Y2R agonists (Eli Lilly, Novo Nordisk), amylin/calcitonin dual agonists (Nordic Biosciences, Amylin Pharmaceuticals), and ghrelin-targeting agents (Noxxon, Cytos) Novel mechanisms : There are several companies taking differentiated (non-incretin) approaches to obesity

The synergy between these agents arises from their complementary actions

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New research to be presented at the European Congress on Obesity (ECO 2025) suggests that weight loss treatments using GLP-1 and dual GLP-1/GIP receptor agonists can lead to significant fat loss with minimal reduction in lean muscle mass