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In addition to the two primary uses for retatrutide, Lilly said it is evaluating the drug's potential for a host of obesity-related medical conditions, including knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal issues, and metabolic dysfunction-associated steatotic liver disease

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This is associated with reduced capacity to utilize fatty acids and glucose, and this impairment promotes lipid accumulation within muscle, aggravating IR and muscle dysfunction