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Smeland et al., 2012
Similar content being viewed by others Introduction Obesity and overweight are the most common modifiable etiologic risk factors for type 2 diabetes (T2D)
The possible cardioprotective mechanisms of GLP-1 RAs include reducing epicardial fat tissue thickness, preventing activation of the reninangiotensinaldosterone system, improving myocardial energy metabolism, reducing systemic inflammation and cardiac oxidative stress, and delaying the progression of atherosclerosis
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Notably, defective PINK1 leads to decreasing beta-oxidation, increasing ceramide accumulation in mitochondria and mitophagy (Vos et al., 2021)
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