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Bottom Line BPC157 remains an experimental peptide with mechanistic plausibility derived from preclinical models but insufficient human data to claim clinical efficacy or long term safety, and its regulatory and anti doping status increase risk for patients and athletes considering unsupervised use

Using the currently approved estimate of 0.25/hr per registration, we estimate an annual burden change of +578.00 hours (+2,312 registrations 0.25 hr/registration) at a cost of +$62,227.48 (+578 hr $107.66/hr for a computer system analyst or equivalent)

Mol Neurobiol 47:632644 Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, Giustetto M, Ferreira TA, Guiducci E, Dumas L, Ragozzino D (2011) Synaptic pruning by microglia is necessary for normal brain development

It also provides the first year in which the accumulated savings are greater than the performance payments